In 1930 and as a young child, Tsuneko Kohashi lives at Enshu in Shizuoka Prefecture. She has a happy life with her parents and two younger sisters. Things change after her father dies from tuberculosis. Her father asked Tsuneko Kohashi to take care of the family in his place. Due to financial difficulties, her mother Kimiko decides to move the family to Tokyo where Tsuneko's grandmother lives.

Toto Nee-chan тривав 1 сезон. Нових епізодів не заплановано.