The story revolves around Shang Jie, the overly critical head of a crime investigation team; Xia Ying, a forensic examiner who is completely engrossed with her profession; Li Xue Kai, a detective and a good tracker; Song Mi, an innocent and ditsy analyst and Ying Ming, a second-generation rich who works as a criminal psychologist. The five form an unlikely team as they are the rejects of the department, yet through teamwork and dedication, they succeed in solving the most unusual murder cases.

Talking Bones ran for 2 seasons. No new episodes are scheduled.