The story begins in a small town in rural Mexico, home to Maria López—a humble, dreamy young woman of indigenous descent—who decides to leave her village for Mexico City in search of work and a better life. Upon arriving in the capital, she begins working as a domestic helper in mansions across wealthy neighborhoods, using her earnings to pay for sewing classes. At one of these homes, she meets Juan Carlos del Villar, a playboy who seduces and wins her over.

Simplemente Maria ran for 1 season. No new episodes are scheduled.