Each episode of this series include multiple segments: The first and last were "Laff-A-Lympics" segments, the other ones were "Captain Caveman and the Teen Angels", "Scooby-Doo" and "Dynomutt" segments. The "Laff-A-Lympics" segments feature 45 Hanna-Barbera cartoon characters (classic and otherwise) competing for gold medals in wacky events. Events include racing on ostriches, camels, kangaroos, rickshaws and unicycles, as well as scavenging for creatures like the Abominable Snowman, vampires, and the Loch Ness Monster.

Scooby's All-Stars тривав 2 сезони. Нових епізодів не заплановано.