Aditya Dev (Vipul Roy) and Manav Desai (Kiku Sharda) are two policemen who work under Commissioner Gogol Chatterjee (Johnny Lever). They are very different in nature but slowly start to become good friends. Dev falls in love with Aisha Natkarni (Kishwar Merchant), who is a lawyer and Desai is in love Aisha's smaller sister Dolly Natkarni (Shweta Gulati). They both live with Neena Natkarni (Ashwini Kalsekar), their mother, a widow and an old friend of Chatterjee. The story revolves around how this characters make a whole series of entertainment around the different cases the policemen solve with lots of comedy and entertainment for the audience.

Partners - Trouble Ho Gayi Double ran for 1 season. No new episodes are scheduled.