Istanbul police commissioner Mehmet Özakin is in charge of serious crime, mainly murder investigations, mostly in the Turkish metropolis. A very modern Turk, he uses up to date Western methods, without prejudice, assisted by bachelor Mustafa Tombul. Even his private life is progressive, his wife Sevim being on the former imperial capital's university staff.

Homicide Unit Istanbul тривав 1 сезон. Нових епізодів не заплановано.