Jess Mastriani was a normal person who only wanted to take over her parents' restaurant in Indiana. But that changed when she was hit by lightning. After that she began seeing visions of missing people. Jess decides to use her newfound ability to be a consultant to the FBI, helping locate missing individuals. Eventually, she is hired by the bureau full-time and trained to become an agent, but her by-the-book nature sometimes clashes with the personality of her partner. Jess and her colleagues work out of the FBI's Washington, D.C., office.

Missing тривав 3 сезони. Нових епізодів не заплановано.