Centering around the lives of pre-teen Hispanic twins named Maya and Miguel Santos and their friends, the program is aimed at promoting multiculturalism and education in general. It is geared to the 5-9 age range. Part of the dialogue in each episode in the English version is in Spanish but only individual words or phrases which are explained in English.

Maya & Miguel тривав 2 сезони. Нових епізодів не заплановано.