A young girl named Ruka, who had been living a wandering life in Osaka, is taken in by Fumi, an elementary school teacher. Later, Ruka spends time in Obihiro, Hokkaido, with Natsuhiko, who was her sister's lover, and forms a friendship with a high school girl named Maori. However, the fate that awaits her is always harsh. After arriving in Tokyo, Ruka becomes a musician and begins singing on the streets under the name Kyrie. There, she reunites with Maori, who now goes by the name Ikko and survives in Tokyo through her ever-changing cosplay and relationships with men. From Ishinomaki, Osaka, and Obihiro to Tokyo—Ruka, while being tossed about by fate, weaves a grand lyrical poem through her determined life.

Luca on the Road ran for 1 season. No new episodes are scheduled.