Lalo Padilla, a chauvinistic man and the director of a popular men's magazine, fell victim to a revenge spell cast by one of his mistresses after he stood her up. Upon waking, Lalo discovered that his body had transformed into that of a woman. Now known as Lola, he must live this way while searching for a way to become Lalo again.

Lalola тривав 1 сезон. Нових епізодів не заплановано.