In the 1920s Victoria and Ángel fall in love in a small town, northern Spain. They are two people both from a different social class, she is the daughter of a wealthy businessman and he comes from a poor family. They are so in love but social norms and circumstances of the era force them to break up. Several years later, they meet again, Victoria as a powerful businesswoman and Ángel as a priest.

La Señora ran for 3 seasons. No new episodes are scheduled.