Trying to make a name for themselves in New York's competitive fashion scene, Ben Epstein and his friend and business partner Cam Calderon use their street knowledge and connections to bring their ambitions to fruition. With the help of Cam's cousin Rene, who is trying to market his own high-energy drink, and their well-connected friend Domingo, the burgeoning entrepreneurs set out to make it big, encountering obstacles along the way that will require all their ingenuity to overcome.

How to Make It in America ran for 2 seasons. No new episodes are scheduled.