Four stylish and ambitious best girlfriends in Harlem, New York City: a rising star professor struggling to make space for her love life; a savvy tech entrepreneur always dating someone new; a no-filter singer; and a hopeless romantic fashion designer. Together, they level up into the next phase of their careers, relationships, and big city dreams.

Harlem тривав 3 сезони. Нових епізодів не заплановано.