A casual encounter between Adriana and Sergio, two former high school friends, triggers the beginning of the game of the keys where four couples generate new sexual and emotional combinations in a dangerous and lustful game. The game consists of everyone putting their keys in a bowl. At random, each one chooses some keys and he must go to spend the night with the owner of the keys. This game will revolutionize the group of friends and their lives. It will make them discover who they are and what they really want.

The Game of Keys ran for 3 seasons. No new episodes are scheduled.