Valentina and Sebastián—known as "Los Camaleones"—are manipulated by "El Amo" into stealing artworks and valuable jewelry worth millions of dollars; if they fail to meet his demands, he wields enough power to kill their only loved ones, who are currently imprisoned because of Augusto Ponce de León. Ponce de León is the police chief—and Solange’s father—as well as a womanizer estranged from Francisca Campos; he is in charge of the "Camaleón" case, which he must solve to secure a political position and gain ever-increasing power.

Camaleones тривав 1 сезон. Нових епізодів не заплановано.