Comedian Amy Sedaris cordially invites you into her home, where she will show off diverse but necessary homemaking skills, from death-bed etiquette, to gutting a fish, to crocheting miniature sweaters for a mice infestation, to entertaining your husband's business associates. As always, Amy will give it her best shot to entertain guests, increase her know-how and her can-do, and attempt to work out personal issues.

At Home with Amy Sedaris ran for 3 seasons. No new episodes are scheduled.