María Alejandra Rivas Cavalier, a young aspiring surgeon with a prestigious family name, joins the highly regarded internship program at Santa María University Hospital. There, alongside a group of new friends and her relationship with renowned surgeon Andrés Guerra, she faces medical and personal challenges that shape her journey. Amid intriguing medical cases and the quest for her own path, the hospital becomes her new home and the stage where friendship, love, and sacrifice intertwine.

A Corazón Abierto тривав 2 сезони. Нових епізодів не заплановано.