In a time when Shanghai was controlled by the merciless warlords, sworn brothers Kiu Ngo-Tin and Kung Siu-San have to rely on each other. Together, the ruthless Siu-San and the cunning Ngo-Tin create a world of their own, but in order to stay on top, Ngo-Tin has no choice but to leave his past behind completely, including his confidant and true love Ku Siu-Lau, a Peking opera apprentice. When Ngo-Tin catches the attention of a local casino boss, he is introduced to Kam Tong, Shanghai's most powerful tycoon. Along with Siu-San, Ngo-Tin and Kam Tong become legendary figures in Shanghai. But success is short-lived as a single city cannot accomodate three leaders; Siu-San and Kam Tong enter a battle for power, creating havoc in Shanghai.

Lord of Shanghai ran for 1 season. No new episodes are scheduled.