Melissa De Sousa is an actress best known for her role as Shelby in the 1999 romantic comedy-drama film The Best Man, its 2013 sequel The Best Man Holiday, Gabriella Jimenez in BET's Reed Between the Lines, and Ana Lopez in Black Lightning. 

Filmography

• 2025Operation: Aunties — Carol
• Bel-Air — Steph
• The Best Man: The Final Chapters — Shelby
• On Becoming a God in Central Florida — Mirta Herrera
• Black Lightning — Chief Ana Lopez
• Ladies of the Law — Tina
• 2015Divas! — Angie
• 2015Supermodel — Det. Lacey
• 2014Cru — Michelle Hughes
• 2013The Best Man Holiday — Shelby
• Elementary — Luz Horowitz
• 2011Ashes — Camille
• Reed Between the Lines — Gabriella Jimenez
• Shameless — Tina
• Single Ladies — Austin Aguilera
• Castle — Liz Penn
• 2008A Good Man Is Hard to Find — Monica
• 2007Bats: Human Harvest — O'Neal
• 2007Constellation — Lucy Boxer
• 2006Saturday Night Life — Darlene Maye
• 2006The Ron Clark Story — Marissa Vega
• Criminal Minds — Adele McCord
• Ghost Whisperer — Christine Nelson
• Second Time Around — Coco Herrera
• 2003Laurel Canyon — Claudia
• 200130 Years to Life
• One on One — Natalie
• 2000Lockdown — Krista
• 2000Miss Congeniality — Karen 'Rhode Island'
• The $treet — Donna Pasqua
• Grown Ups — Donna Parris
• 1999The Best Man — Shelby
• Damon — Stacy Phillips
• 1998Ride — Leta
• Moesha — Jennifer
• The Wayans Bros. — Charmaine
• ER — Estella
• Valley of the Dolls — Neely O'Hara
• Living Single — Carmen, Lisa

Appearances as themselves (1)

• The Kelly Clarkson Show — Self