After a few bit parts, Holly landed a leading role as Kimberly in TV drama Picket Fences (1992). This show ran for 4 years, winning Holly critical acclaim and a Young Actors award. After the show ended, Holly starred in more roles in TV movies, enjoying her marriage and career success. This wasn't to last; in 1997, she divorced husband Bryan Travis Smith and yearned for more challenging roles. Then in 1998, Holly's good friend Shannen Doherty told her about a new television show based around three sisters who happen to be witches, who save the world from evil. Holly auditioned for the middle sister, won the role and is now known world wide for her portrayal of Piper Halliwell in the WB smash hit show Charmed (1998). Holly now lives in Burbank with her husband and their three sons.

Filmography

• 2018Sharkwater Extinction — Producer
• 2016Love's Complicated — Lea Townsend
• 2016Why Just One? — Associate Producer
• Off the Map — Herself, Executive Producer, Creator
• Pretty Little Liars — Ella Montgomery
• 2007Point of Entry — Kathy Alden
• Grey's Anatomy — Heidi Peterson
• 2003See Jane Date — Natasha Nutley
• 2001Ocean's Eleven — Holly Marie Combs (uncredited)
• The Nightmare Room — Girl (uncredited)
• Charmed — Piper Halliwell, Producer
• 1997Love's Deadly Triangle: The Texas Cadet Murder — Diane Zamora
• 1997Our Mother's Murder — Alex Morrell
• Relativity — Anne Pryce
• 1996Sins of Silence — Sophie DiMatteo
• 1995A Reason to Believe — Sharon
• 1994A Perfect Stranger — Amanda Hale
• 1992Chain of Desire — Diana
• 1992Dr. Giggles — Jennifer Campbell
• Picket Fences — Kimberly Brock
• 1992Simple Men — Kim
• 1989Born on the Fourth of July — Jenny
• 1989New York Stories — Costume Party Guest
• 1988Sweet Hearts Dance — Debs Boon
• American Playhouse — Kim

Appearances as themselves (5)

• Hell's Kitchen — Self - Restaurant Patron
• The Reichen Show — Self
• Good Day Live — Self
• Teen Choice Awards — Self
• Intimate Portrait — Self