The story revolves around four teens - the good-looking twins Asaba Yuuta and Yuuki, the effeminate Matsuoka Shun, and the class head Tsukahara Kaname - who have known each other since early childhood. While they are not necessarily good or bad friends, they continue to hang out well into high school. The half-Japanese transfer student Tachibana Chizuru joins the circle of friends in this comedy about the everyday life of adolescence.

You and Me ran for 2 seasons. No new episodes are scheduled.