Kimihiro Watanuki is a high school student plagued by ayakashi spirits, both of which are invisible to everyone else but him. The series begins when Watanuki stumbles, seemingly by chance, into a shop that grants wishes. The shop is owned by Yūko Ichihara, a mysterious witch of many names and esoteric renown. For a price, she offers to grant Watanuki's wish to be rid of the spirits. The price, according to Yūko, must be of equal value; so, as payment, he must become Yūko's temporary, part-time cook and housekeeper.

xxxHOLiC ran for 2 seasons. No new episodes are scheduled.