Following World War V, a global-scale conflict fought with non-nuclear weapons that almost halved the earth's population, the city-nation of Olympus stands as a beacon of hope in a world of chaos. The utopian metropolis is governed by Gaia, a vast artificial intelligence, and administered by genetically engineered humanoids known as bioroids. Although Olympus seems like a peaceful city on the surface, racial (human vs. bioroids vs. cyborgs), religious, and political conflicts lurk underneath -threatening to overturn the delicately balanced peace of this so-called utopia.

Appleseed XIII ran for 1 season. No new episodes are scheduled.