Shugo Chara! centers on elementary school girl Amu Hinamori, whose popular exterior, referred to as "cool and spicy" by her classmates, contrasts with her introverted personality. When Amu wishes for the courage to be reborn as her would-be self, she is surprised to find three colorful eggs the next morning, which hatch into three Guardian Characters: Ran, Miki, and Su.

Shugo Chara! ran for 3 seasons. No new episodes are scheduled.