Kakeru, a former elite runner at high school, is chased for stealing food. He is saved by Kansei University student Haiji, who is also a runner. Haiji persuades Kakeru to live in the old apartment "Chikuseisou" where he plans to team up with fellow residents to enter Hakone Ekiden Marathon, one of the most prominent university races in Japan. Kakeru soon finds out that all of the residents except for Haiji and himself are complete novices.

Run with the Wind ran for 1 season. No new episodes are scheduled.