High school student Chiyo Sakura has a crush on schoolmate Umetarō Nozaki, but when she confesses her love to him, he mistakes her for a fan and gives her an autograph. When she says that she always wants to be with him, he invites her to his house and has her help on some drawings. Chiyo discovers that Nozaki is actually a renowned shōjo manga artist named Sakiko Yumeno. She then agrees to be his assistant in order to get closer to him. As they work on his manga Let's Fall in Love (恋しよっ), they encounter other schoolmates who assist them or serve as inspirations for characters in the stories.

Monthly Girls' Nozaki-kun ran for 1 season. No new episodes are scheduled.