As high school reaches its midpoint, Koichi Asakura—who dreams of studying design at art school—has his plans shaken by explosive graffiti on a museum wall. The artist is Eren Yamagishi, a left-handed girl who buried her talent after a past incident. Drawn together by art, Koichi pursues design as Eren returns to painting, but fear, ambition, and old scars threaten their paths.

Eren the Southpaw ran for 1 season. No new episodes are scheduled.