Masaru, is a second year Junior High student, and is undefeated in battle, He meets the Digital Monster Agumon, who has escaped from DATS, a secret government organization. Despite terrible first impressions, the two become best friends by talking with their "fists". With others, Masaru and Agumon work to investigate various incidents involving the Digital World and Digital Monsters, to try and get to the bottom of things.

Digimon Data Squad ran for 1 season. No new episodes are scheduled.