Ren Mihashi was the ace of his middle school's baseball team, but due to his poor pitching, they could never win. Constant losses eventually lead to his teammates bullying him and reached the point where his teammates no longer tried to win, causing Mihashi to graduate with little self-esteem. As a result, Mihashi decides to go to a high school in a different prefecture where he has no intention of playing baseball. Unfortunately, upon his arrival at Nishiura High, he is dragged into joining their new team as the starting pitcher.

Big Windup! тривав 2 сезони. Нових епізодів не заплановано.